Good, now that I've got some more time :
As an owner of 2 Define R5 cases (one housing my 10-drive NAS, the other my secondary PC), I'd like to point out 1 flaw that can have an effect on how you'd like to set up your fans : there's a huge unfiltered opening near the 5.25" bays, and with a fairly neutral fan setup it has a tendency to suck in large amounts of dust through said opening (because the CPU cooler will generate front-to-back airflow in the top third-ish of the case).
A possible fix for that is to use duct tape to cover the hole between the 5.25" cage and the front cover, between the red lines on this pic :
With that fix, the case can no longer draw in unfiltered air through there.
I did that on both my R5-es ... R5s ... R5ii ... ermm ... what's the plural for "R5"? Here's a pic of it on my NAS.
Another fix is to simply make sure that there is so much positive pressure inside the case that the CPU simply can't draw air from all the way up front. To achieve that, I'd put in 2 more intake fans than exhaust fans.
Personally I prefer the duct tape method though. But hey, you can have both the tape and massive positive pressure if you want.
3 fans (2 in, 1 out) should be enough to keep a 4770 with a decent cooler (like the 212 EVO you mentioned) and a 1070 at a reasonable temperature. It'll also keep it fairly quiet because you can keep all the moduvents in place.
In this configuration, I'd take the stock rear fan and bolt it on the front, so you have matching fans there. Then you can get anything else for the opening at the back.
5 fans (3 in, 2 out) will be more than enough for even an SLI setup. For that cooling setup, I'd also move the stock rear fan to the front to get a matching pair there, put another intake fan on the floor (put the small drivecage up against the 5.25" bays and leave out the large one). For exhaust I'd put a fan in the rear opening and remove the rear moduvent so you can put a fan there.
With the 2 intakes and 2 exhausts you mentioned, you'll not get a neutral setup, you'll get negative pressure because the filter on the intake fans and the obstruction of the drive cage (if you leave it in) will reduce the efficiency of the fans, meaning that the exhaust fans can move more air out than the intake fans can suck in. With negative pressure you'll suck in even more dust than with neutral pressure, so make sure you have at least 1 fan extra pulling in air.
Don't let this one flaw put you off, the R5 is one hell of a case and a pleasure to build in.