Hello @Edin_Gacic ! Yes, it works perfectly fine with Windows 10. Note that you will need to download the EPYC SP3 drivers as it seems Windows doesn’t download them on its own but other than that everything is fully plug-and-play.
I’ve had no stability issue whatsoever except when I used the Milan BIOS update with a Rome processor : it works but is unstable. Make sure to update your BIOS to match the processor type you’re using; you shouldn’t assume that the latest BIOS will work with any EPYC.
I have run it with a 3090 FE myself and that comes with mechanical issues : those cards are very heavy, and the motherboard has plastic PCIe slots, non-reinforced, and surface mount. It’s a server board so it’s not meant to be mounted vertically in a tower case.
Also, the PCB is extra-thick (12 or 16 layers, maybe) so your motherboard tray screws might be too short. Be careful with that. You may need to use longer screws with the same thread, I used screws for optical drives, for example.
On the software side, nothing to say : it all works beautifully. If you haven’t already, you should go through the EPYC Milan workstation thread, I’ve contributed photos (including thermal) that you might find useful. As well as a lot of information by lots of people including our Lord and Savior @wendell :