Virt-manager itself, not really. There should be some guides out there, but virt-manager is easy to get into. For GPU passthrough, I suggest you follow a few of the passthrough guides.
I cannot seem to find the one with CPU pinning, but I remember Wendell did a wiki for that, but I don’t know if it was one of the many Fedora VFIO guides (2019 to 2021), the Arch VFIO, Ubuntu VFIO or Pop!_OS VFIO guide. But I seem to recall he used a TR 2nd gen, but I could be wrong.