Few Questions about thunderbolt and video

I am wondering if you have a thunderbolt port and use a display adapter and hook up 3 displays does it make it one large format display or are they all separate and can be orientated differently?

For example i have 3 screens.

left center and a vertical orientated right one. Now you have to tell it that it is flipped so that it works correctly, can you still do this if you use an adapter such as a displayport hub?

Also how well would this work on a linux setup as well? intell cpu and nvidia gpu