You can, but it'll require some ingenuity.
My first idea would be to mount the drive on its side, using the mounting holes for bottom fans. I mounted one in my own R5 just to show the idea. Unfortunately I have PCIE cables ziptied to the bottom, so I can't move the HDD around as much as I'd like. Still, this should give you an idea.
In this pic I have the drive mounted with just the 2 closest screw holes on the side.
Apologies for the dust, by the way. This PC isn't a show queen, it's a work horse.
View of the bottom, showing fan mounting holes that I used for mounting the HDD.
If it weren't for the PCI cables, I would be able to move the HDD back almost all the way to the PSU and use the outermost screw holes to attach it. That would give it a bit more stability. 2 screws is enough if the PC is stable, but not ideal if you plan to move it around. So if you mount the HDD this way, don't shake the case it if you take it outside to remove the dust.
Option 2 would be to lay it on the floor, but the HDD's mounting holes only align with the pattern in the floor if you mount the drive sideways or at a 45° angle. If you want to mount it longitudinally, you'd better be ready to take a file or a dremel to the bottom of the case..
Not only is it not laying perfectly flush due to it overlapping the (elevated) fan mounts, space for the SATA cables is extremely tight. There's maybe an inch between the drive's SATA power connector and the motherboard tray.
The R5 has a full-length filter on the bottom. While you have to pull it a bit to get it over the higher-profile screws (those where you can put a wrench on the head), it'll still slide over the low-profile ones without touching them. With either option you can retain the filter, it does go over even the high-profile screws, as shown here.
Hope this helps