The case is basically untouched, I just had to ziptie two corners and use some motherboard standoffs upside down to get it in. But be careful, we are talking different boards here.
I would not try to fit AIOs in there and honestly I don't see the point of that. My CPUs don't hit 70C and I can sleep next to the thing.
The Asus WS boards are great as far as I can tell. I have the Z9PE-D8 WS in my main rig, also running 2670s.