Focusrite just works but is cheap stuff so has some quirks. It's usually a better idea to get hardwired class compliant stuff like the Steinberg UR series, which is made with *nix class compliance in mind from the start. Not that, right now, that gives you a benefit other than the superior build quality and native modern Yamaha 192/24 ADC/DAC and the larger headroom pres, but in the future, you'll know that it will always enjoy maximum support and compatibility in Linux.
But even interfaces that are long forgotten in Windows, still work great in Linux, and certain software, for instance Digitech's patch editing software, enjoys great open source support in Linux, but doesn't function any more on Windows. Harman Group products are pretty popular, so that's definitely a bonus in Linux.
VST's are super readily available in all kinds in Linux. I don't know if you saw the post about the open source effect devices from MOD Devices I posted earlier this week or last week or so. These things sell like crazy, and all it is is an LV2 host (Ladspa Version 2, the evolution of LADSPA, which is the equivalent to VST. LV2 is more like a better version of VSTi and then some, because it also includes things like impulse response loaders with a real mathematical background, which is possible in Linux without causing latencies... in Linux, you can have a latency free convolver for free, even a real time one, without much impact on the system, whereas a Windows or MacOS using music producer you would typically buy a hardware (linux-based) IR loader (e.g. the very popular Two-Notes Torpedo Studio for 1500+ EUR, I actually have one, the latency is rated by Two-Notes at 5.063 ms in normal mode, that's end-to-end, so that's actually not bad, but a convolver running as a DAW plugin in a preemptible kernel multimedia linux distro will add less latency), to have a low-latency convolver that doesn't take all of the system resources. Well, in all forums, including for instance the MOD Devices forum, you'll find the resources to all plugins ever... and the big benefit of open source development is not only that the offering is much greater, as in the number of available plugins is much greater... because it's open source, there is also community development... users actually are part of the development of plugins, and can make remarks and try betas out and fork plugins if they have a different idea, etc... the whole things is much more creative and interactive, and of course much better value for money... and because there are no vendors that change GUI's and file formats every couple of years to make everyone buy expensive updates, the GUI and plugins are always never obsolete, and everything works everywhere, so you can exchange files amongst users, you don't need a dongle, there is no DRM, etc...
There are also independent communities like linuxmusicians, with fora and active knowledge sharing. It's a spirit like in the nineties, there is a lot of collaboration, exchange, leverage, as it should be in the creative industry. All of those users who still use commercial walled garden solutions are getting seriously isolated from what's really happening, from the explosion in the creative sector that's happening. Remember Waves, the vendor of the very expensive pro plugins that came to the scene about 10 years or so ago? They still have those expensive plugins, but they also do open source plugins that are actually more modern evolutions of their commercial plugins.
Anyway, too much to mention. If you're interested in jumping aboard of the new creative craze (which is not only a fact in music, but also in graphical arts, where open source is also catalysing the scene like crazy, with a lot of exciting new industry standard open source software coming out as a consequence), visit a few open source fora, like the fora of linux musicians, the fora of creative distros like KxStudio, the fora of linux-based commercial products vendors like Harman Group products, Korg, Yamaha, etc... but also of indie open source specific companies.