Windows 10 Registry differences

So silly question. Before I start making more of an ass of myself. I have it on the authority from a friend of mine who does do development and testing work in the industry. He has stated, registry hacks won't work the same way like they used to in previous versions of Windows. An example of this would be, forcing an Nvidia GPU to run PhysX only while using an AMD GPU for the rest. Of course this can lead to occasional crashes. He says it is more of an indexing type system now, instead of from what I understood the registry was a tool box of saved settings.

I however, have not found these claims any where on the internet. I also know my friend isn't full of shit either, because he generally has a better idea on tons of topics better than I. So thoughts people? I was thinking @wendell @Logan @Kat or @DeusQain might have an idea.

I have scoured MSDN, other official MS outlets, as well as reliable forums and blogs. Finding something relevant other than "herp derp lets tweak 10 and it might break?"

I think this may actually be the case, I'm not familiar enough with the registry to know for certain; however some hacks that used to work in several previous versions of windows haven't been working in Windows 10 from what I've heard. Will definitely have to look more into this.

I've gotten some more information. The main difference between 10 and below is the registry is not always loaded into active memory like it used to be. This was done as a security measure to prevent people getting into it without the user knowing. To kind of explain how it is now. It works like Active Directory or sort of pulls from an architecture like it. Keeping the registry separate rather than integrated. There is something on the MSDN pages about this. That's where I am looking currently.

You may find the information on this site useful.

Link: http://winsupersite.com/