So silly question. Before I start making more of an ass of myself. I have it on the authority from a friend of mine who does do development and testing work in the industry. He has stated, registry hacks won't work the same way like they used to in previous versions of Windows. An example of this would be, forcing an Nvidia GPU to run PhysX only while using an AMD GPU for the rest. Of course this can lead to occasional crashes. He says it is more of an indexing type system now, instead of from what I understood the registry was a tool box of saved settings.
I however, have not found these claims any where on the internet. I also know my friend isn't full of shit either, because he generally has a better idea on tons of topics better than I. So thoughts people? I was thinking @wendell @Logan @Kat or @DeusQain might have an idea.
I have scoured MSDN, other official MS outlets, as well as reliable forums and blogs. Finding something relevant other than "herp derp lets tweak 10 and it might break?"