I'm REALLY liking Vladis Story, I also love Binding of Isaac. And I also really really like the multitude of beatmap games like Audiosurf/Osu!/Beatmania.
I haven't played Indie games for quite a while, but for me, my all time favourite would be Minecraft, I had plenty of great moments playing that online with friends and meeting new people is something I haven't got from any other game.
I'd have to agree with The Stanley Parable, just because it makes some interesting points about the gaming industry using hilarious dialogue. (although Cave Story and Minecraft are up there too)