modern chipsets have been pretty stable in my experience. I have a media server I helped setup for a friend using the USB das I did a video on. asustor also has a nice USB 10g das. if you don’t scale past about 4 drives and use a fs that gives early warning of corruption it’s fine.
consider the sus sats controllers like j micron which when they overheat cause dats corruption. good USB isn’t any worse than the worst sata controllers