I'm loving the new ReShade 3.0. It's so easy to configure because of it's integrated UI making it easier to experiment without going in-and-out of the game. A lot easier than the cumbersome New Vegas ENB.
Settings and Mod Lists
In-game Video Settings:
1080p Borderless Window, Ultra, 4x AA, 16x Anisotropic, Texture High.
ReShade Effects:
HDR, LumaSharpen, Vibrance, Curves, LiftGammaGain, Vignette, AmbientLight, MotionBlur.
Mod List:
My only gripe is because of how New Vegas handles first-person view (the first-person hand model is treated as a camera overlay instead of being a part of the 3d world space), Ambient Occlusion and Reflective Bumpmapping are seen through your arms.
With enough tweaking, I could actually make New Vegas almost like Fallout 4.