Pre installed windows apps on WINE

Hello, i got a question.

Since im thinking to transfering to linux and really giving it a go this time, a thing that interests me is this:
Is it possible for WINE to use a already installed app.

Let me make it a bit more clear. Windows is ATM installed on C (which is an SSD) and i use my HDD for storage (D/ ) everything works nice and neat yada yada yada. Now, if i install linux on C, and leave D untouched, will WINE be able to run programs from D (the complete folder is there) or will i have to download everything again?

So windows is installed on C, but you keep all windows software on D, and you want to run those softwares under linux using WINE?

yeah, just switch Windows on C with linux and run them with WINE, possible?

It really depends if the programs car run using WINE. What programs do you want to run?
EDIT: if you want to know if a specific program runs on WINE, search it here: https://appdb.winehq.org/