Mouse/Keyboard broken in windows only

Hey guys, so yesterday I swapped my old gpu into my brothers computer.  Thought everything would work fine but when we booted into windows the mouse and keyboard wouldn't work.  We made sure to delete the old drivers, and we tried different mouses/keyboards and all the usb ports.  The mouse and keyboard both work in the BIOS and in his ubuntu HDD, so the issue has to be windows.  We tried unplugging them after booting up and plugging back in but that didn't work either.  Any idea what the issue might be?  Only other info is the copy of windows never got an activation key, if that plays a role.