EDIT, summary of what I picked up from the video above.
Not really sure what the exact AA (video said "Temporal AA/HBAO", not sure what that's supposed to mean) setting he was using were, but IMO, at 1440p/2160p, you don't need it.
Anything lower than an RX 480 is going to have a hard time pushing ultra 1080p@60. If you want to play 4k, you're going to need SLI 1080's to get enough performance. The 1080ti was pushing 43 avg with a min of 37 at 4k ultra.
Something interesting to note is that this could be considered undeniable proof that the soon-to-be-released consoles are not going to be able to push AAA titles at 4k.
I'm a bit awestruck by the system requirements of ME:A, but I haven't yet played it, so I'll update tomorrow to say if the requirements are worth it.