On the latest Tek, Logan mentioned that the thing holding him back for Linux as Daily Driver is the Audio Authoring tool that he uses.
While LMMS may not be the solution, a Virtual Machine is the solution.
I have a Virtual Machine for Adobe Photoshop and Illustrator and it runs them both fine while dedicating less than a single GB of RAM to them. Logan, your access to hardware is so easily compatible with this aspect that I'd suggest this rather than trying to find an alternative or even trying to run it through WINE.
Virtual Machine to run Windows Apps is annoying for sure but it is a fantastic solution to make Linux your daily driver. I've been doing this structure for 6+ years and it works fantastic. I get to have all the apps I need while also getting to run an operating system that isn't fighting me every day and isn't trying to make me hate computers.
Please give it a shot, I think it will solve your issue.