KM Switch mouse roaming with extended displays

Hi, I have a question regarding the 4 port KM switch with mouse roaming. Would it be possible to have two PCs each with two monitors, and have the mouse romaing still work between at least two of the monitors?

In other words, in the setup in the image below would it be possible to have the roaming work, at least between monitors 1 and 3? If that isn’t possible, I assume it is still possible to switch control via the physical KM switch buttons and the keyboard shortcuts, and it is just as instantaneous?