Not sure why youd spend so much on a gpu, the value of a gpu halves about every year. If you want to spend that much on a single gpu card wait for the hd 9970, it should be out this month and become the fastest single gpu card. I think i heard somewhere that it will have 4 gb ram, but that could easily be wrong, it should be at least 3 though. I cannot believe that the 9970 will cost above 700, so you can throw some money on the streets or burn up some Benjamin Franklins.
You should look into a GPU, CPU, and mobo upgrade while you're at it. GTX 780 if you want to Fold, 7950/70 if you want to game. If you get the 780, youprobably can't get a very good CPU/mobo combo in there (bottom line Z87 + 4670k or 8350 with moderate mobo), but with a 7950 or 7970, which are kickass cards for the cost, then you could get a 4770k, with a really nice mobo, or even another SSD.
Are titans under $1000? like $999? anyway... I love my 780. Plays everything on Ultra at 1440p. I went 780 just because more value oriented from the titan saving $300 for what %5 increase I think?
I don't know. Just buy the most expensive since you're out to impress all your friends.
Total $900 on Newegg. $30 more for a 7950, and $100 for a extra hard drive.
Point is you can do alot more for $1000.
7950 CF or GTX 760 SLI is under $600 and that can run anything in 1440p. In less you have 3 2560x1600 monitors (which in that case GTX 780 SLI) then there's no point spending more then you should.