do you think tech wise this would make a difference in game play? having Intel Skylake and AMD fury?
It will work fine, Intel has no reason to hinder the performance of AMD GPUs, they don't really compete in that field. And AMD isn't going to make their hardware perform for the worse in any scenario intentionally. In fact it's a good idea due to getting an integrated GPU on your CPU with Intel, and having a fallback plan.
Thank you for your help.