I've not got much hope for this one, but here goes.
i've been trying to play the first Sly Cooper game (Thievius Raccoonus) with PCSX2. Before you bother asking, yes, I own it. I don't want to dig the console out and hook it up to some screen or other and maybe find that it's broken, etc.
Anyway, so I've encountered a game breaking bug. This bug is apparently previously known; it's supposedly triggered when you use a non-Sony memory stick or a GameShark. What happens is that, first, the game considers your key count to be 1 less than it should be, and second, some (apparently random) grab-able objects just silently break and can't be activated.
I've tried everything I can think of. I've turned off speedhacks, I've turned off HW hacks, all the antialising options, 16:9, etc, and I also changed from the virtual memory card I was using initially to the "standard sony" size.