So, let’s take a look at your requirements: Fedora, Win legacy stuff to work on day one because you need it for work.
I recommend getting a dual monitor setup (in case you don’t have that already) - I think it’s unbeatable for productivity (except maybe for triple, quad, … I digress).
Install Windows plus any tool you need in Box on Fedora which works without prayers. You max the box window on one screen, you work in Linux native apps on the other, your mouse, clipboard, focus changes as you expect. If you pick the right background in Windows you won’t even notice it’s there.
This will give you all the time in the world to figure out the depths of wine. Plan on a long time. I use Fedora as a daily driver for a couple of years, generally Linux for 30+. I cannot figure out wine.
That’s why there are so many apps that promise to make wine work (Proton, Lutris, etc.).