Currently running Avast Business Security, but I’ve become increasingly unhappy with it over the years and I’m considering jumping ship. The new cloud UI sucks, it murders the battery on laptops with E-cores, it breaks Okta sync on my domain controllers, etc.
Any suggestions for better endpoint protection for Windows, Mac, and servers? Need ~300 seats and competitive pricing (non-profit)
Are you even required by a government agency to have an antivirus?
If you’re wanting to cover Windows clients, Windows servers and Mac desktops, I’d really consider checking out MS Defender. We’re running it at roughly the same company size as you (350-ish Win10/11 client seats, 150-odd Win servers, a handful of Macs) and I’ve found the various configuration portals etc decent. Also works on most mainstream Linux flavours (we’ve got a handful of Ubuntu LTS servers that it’s quite happy on).
If you’re already using M365 etc (E3 or E5) it’s already included for client devices, or it’s pretty cheap for individual purchase without all the associated bumph (“Microsoft Defender for Endpoint P1”). MS also do pretty established discounting for non-profit orgs if yours qualifies.
If you use any corp firewall products, several AVs have bundle deals. On the other hand if you’re trying to avoid “one-stop” SaaS, here is one good option:
https://www.sophos.com/en-us/products/endpoint-antivirus
Trend has an Endpoint AV, fairly similar to Sophos of being less CPU/RAM hogging.
Morphisec
What about CrowdStrike? If you’re a non-profit and qualify, then you might be able to get into CrowdStrike’s pro-bono program.
+1 here , its very solid option if you already have M365 or you are planning on getting it, it will be included in most plans.
Why get poorly integrated third party solution if you can have this?
The organisation I work for has rolled out MS Defender across all devices, mac, Windows and I even believe Linux.
In my experience don’t trust MS Defender, it has been caught randomly nuking folders and SQL databases for even MS apps like Access & Visual Studio 
In terms of MS Defender, not really sure in which direction to recommend. There is this channel - https://www.youtube.com/@pcsecuritychannel, which does some research and review. But some times I get the impression that the author does get a few $$$ if he recommends the “right stuff” (like MalwareBytes). But you can find a “I ran 100 malwares against A, B, C avs”. Maybe it will give some idea.
Flashbacks to when Defender ASR deleted a slew of shortcuts from the Start menu and the desktop. That was a fun day.
Have you heard about Crowdstrike incident with broken update causing BSOD and affecting whole world?
Lol, that aged well…
It was alright until it broke the Internet on a Friday 
sorry, my joke was me being a dick
I was totally laughing my ass off when I saw that today tho
and yeah, half the world would not have been using it for ages, silently… until it’s a little less silent today 
Don’t apologize i said the same thing when i read that 
Defender for endpoint is reasonable. And low cost.