I assume your component selection is based on the software used and not “it is expensive”
When you are set on a Fractal Design case, go for one of the “Meshify”-versions.
I would recommend something like the Supermicro 743TQ-1200B-SQ or InWin IW-PL689
Even 750W PSU would be enough for one titan.
Maybe look at the SeaSonic Focus or Prime Series.
A 360mm AIO is overkill for a 3950x.
For uptime, you would want air cooling anyway.
- Noctua NG-U12A
- BeQuiet DarkRock Pro4
- Noctua NH-D14
- Thermalright Macho series
- Silverstone HE01-V2
While the Noctua Chromax series are nice fans, the Redux series would be enough (and cheaper).
Other options are EK Varder or NoiseBlocker.
Storage wise, you got a lot of SSDs there.
Might want to throw in a big HDD or two for bulk storage.