2Rx4 vs 2Rx8 Compatibility?

If a motherboard states, the Max. Capacity per DIMM is RDIMM: 128GB (2Rx4) would 2Rx8 also work? Would it be better to go with 1Rx4 instead if 2Rx4 isn’t available?

Welcome,

The only way to achieve that density with the alternative configurations mentioned is going to 32gb dies which do need UEFI support, I wouldn’t necessarily take it as a given than your existing BIOS supports these new dies.
Also I’ve never actually seen a RDIMM in the wild with 32gb dies.

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Sorry yes these are 32GB sticks I’m looking at. I can get 1Rx4 or 2Rx8 but not sure if the 2Rx8 works when it says the max capacity is 2Rx4 or not?

2Rx8 will work, but it will only be half the size of the 2Rx4 RDIMM in the same die class (16gb, 24gb, 32gb).

My mental math didn’t realize it earlier, but a 128GB dual rank x4 organized RDIMM is a 32gb die RDIMM.

Why don’t you actually say which specific Motherboard or platform and DDR generation you’re talking about? Cause your hypothetical question is literally worth nothing.
In many cases you can just straight ignore the Motherboard max capacity. Vendors tend to put on the specs the highest RAM capacity AT THE TIME OF RELEASE and never update manuals as higher DIMM capacities became available, and I can name out of memory 4 examples of platforms that can support more RAM than Motherboard specs officially say.